09/25/18 - 9:45 AM to 10:45 AM
Crawford Memorial Lecture: Professor Dongping Zhong
Bryce L. Crawford Memorial Lecture
Dynamics and Mechanisms of UV-Preventing Biological Photomachines
UV radiation is harmful to biological species in nature. In order to prevent UV-radiation damage, one needs to sense UV radiation to send a signal to trigger a series of protection processes to avoid severe damage and recently a UV photoreceptor, UVR8, has been discovered for such function. On the other side, if damage is caused, one should efficiently repair such damage and one photoenzyme, photolyase, has been recently studied extensively. In this talk, we summarize our detailed studies of these two biological photomachines by following the entire dynamic evolution with various elementary processes of energy transfer, electron transfer and biomolecular transformation within femtosecond timescales. We revealed the photocycles of two photomachines at the most fundamental level and elucidated their molecular mechanisms, providing new insights how the biological photomachines collectively function with higher efficiency.
Dongping Zhong received his Bachelor of Science degree in laser physics from Huazhong University of Science and Technology (China) and his doctorate in chemistry from California Institute of Technology in 1999, under Professor Ahmed H. Zewail. For his doctorate work, Zhong received the Herbert Newby McCoy Award and the Milton and Francis Clauser Doctoral Prize from the California Institute of Technology. He continued his post-doctoral research in the same group with focus on protein dynamics. In 2002, he joined Ohio State University as an assistant professor. Currently, he is the Robert Smith Professor of Physics and a professor of chemistry and biochemistry. He is a Packard Fellow, Sloan Fellow, and Camille Dreyfus Teacher-Scholar as well as the recipient of a National Science Foundation CAREER award.
Research in Professor Zhong's group is directed toward understanding the nature of elementary processes in biological systems. His researchers relate dynamics and structures to functions at the most fundamental level with state-of-the-art femtosecond lasers and molecular biology methods. The laboratory ultimately will have the capability of time resolution from femtosecond to millisecond (second) so biological systems can be prepared and studied at the single molecule level. Researchers are currently focusing on studies of molecular recognition and ultrafast protein dynamics of several important biological systems.
Bryce L. Crawford Memorial Lectureship
Bryce L. Crawford Jr. was a renowned Department of Chemistry professor and scientist. He died in September 2011, at the age of 96. He joined the department in 1940, and became a full professor of physical chemistry in 1946. He was chair of the department from 1955 to 1960, and was dean of the graduate school from 1960 to 1972. He retired in 1985. He loved studying molecular vibrations and force constants, and the experimental side of molecular spectroscopy and molecular structure. During World War II, Crawford worked in research on rocket propellants, making significant contributions to rocketry, and the development of solid propellants for the much larger rockets that evolved after the war. Crawford received many honors during his career, including the prestigious American Chemical Society Priestley Medal; and being named a Fellow of the Society for Applied Spectroscopy, a Guggenheim Fellow at the California Institute of Technology, and a Fulbright Fellow at Oxford University. He held the distinction of membership in three honorary science academies, and was actively involved in many professional associations.