01/22/19 - 9:45 AM to 11:00 AM
Department Seminar: C. Michael McGuirk, Ph.D.
Stimuli-Responsive Coordination Constructs
The performance of enzymes is reliant on the spatially defined active site environment that encompasses catalytically participatory atoms. Many enzymes leverage this dependence to desirably regulate their function through reversible stimulus-induced structural changes to the active site. Inspired by this control, my work has focused on the realization of stimuli-responsive coordination architectures for the by-design regulation of catalytic activity and chemically selective gas adsorption. In the Mirkin Group at Northwestern University, we demonstrated that by integrating hydrogen bond-donating organocatalysts into a stimuli-responsive hemilable coordination construct, catalytic activity could be regulated through the steric modulation of competitive intermolecular interactions,1,2 creating opportunities for the in situ regulation of polymer composition. Since joining the Long Group at UC–Berkeley, efforts have focused on harnessing stimuli-responsive metal–organic frameworks (MOFs) that display non-classical gas adsorption behavior for a range of applications. In particular, we have reported the profound influence of metal-substitution on CO2 and CH4 adsorption behavior in a class of flexible frameworks with “gated” adsorption.3 Additionally, we have shown that diamine-appended MOFs are capable of reversibly adsorbing the toxic commodity chemical CS2 through a cooperative chemical adsorption pathway.4 Taking together, these works demonstrate the power of coordination constructs to mimic biology in using structural responses to a stimulus to desirably regulate function.
- McGuirk, C.M.; Mendez-Arroyo, J.; Lifschitz, A.M.; Mirkin, C.A. Allosteric Regulation of Supramolecular Oligomerization and Catalytic Activity via Coordination-Based Control of Competitive Hydrogen Bonding Events. J. Am. Chem. Soc. 2014, 136, 16594.
- McGuirk, C.M.; Mendez-Arroyo, J.; d’Aquino, A.I.; Stern, C.L.; Mirkin, C.A. A Concerted Two-Prong Approach to the in Situ Allosteric Regulation of Bifunctional Catalysis. Chem. Sci. 2016, 7, 6674.
- McGuirk, C.M.; Runčevski, T.; Oktawiec, J.; Turkiewicz, A.; Taylor, M.K.; Long J.R.; J. Am. Chem. Soc. 2018, 140, 15924
C. Michael McGuirk, Ph.D.
C, Michael McGuirk, Ph.D., is a post-doctoral fellow working with Professor Jeffrey Long at the University of California, Berkeley. He received his bachelor’s degree in chemistry with a minor in biochemistry from the University of Minnesota, and earned his doctorate at Northwestern University, working with Professor Chad Mirkin. Current research encompasses eludiating the molecular origins of step-shaped adsorption in metal-organic frameworks.
Event DetailsLocation: 331 Smith HallHost: Professor Lawrence Que Jr.Speakers:
- C. Michael McGuirk, Ph.D.
- Department of Chemistry
- University of California, Berkeley