01/15/19 - 9:45 AM to 11:00 AM
Department Seminar: Courtney Roberts, Ph.D.
Developing and Improving Organic Reactions through Catalyst Design
Improving organic reactions through catalyst design is an important goal for synthetic chemists. But how do we do this? In this talk, the impact of catalyst design on two different reactions will be explored. The first reaction that will be investigated is alkene hydrofunctionalization–the addition of an H–nucleophile bond across a C–C double bond. By looking at challenging steps in the catalytic cycle for alkene hydrofunctionalization and rationally designing a catalyst that would eliminate these challenges, we were able to develop a general catalyst for a variety of nucleophiles to participate in this reaction. The second reaction that will be explored is a C–H functionalization that was developed through designing a catalytic cycle that involves the first example of C(sp3)–H activation at Ni(IV). By understanding the fundamental organometallic chemistry of high oxidation state Ni, a catalytic C–H chlorination reaction has been developed.
Courtney C. Roberts obtained her Bachelor of Science degree in chemistry from Pepperdine University in Los Angeles, CA. She then pursued her graduate studies at the University of North Carolina at Chapel Hill, becoming the first graduate student in the laboratory of Professor Simon Meek. After completing her doctorate in 2016, Courtney became a post-doctoral research fellow in the laboratory of Professor Melanie Sanford at the University of Michigan where she is currently exploring C–H functionalization reactions using high valent Ni.
Event DetailsLocation: 331 Smith HallHost: Professor Christopher DouglasSpeakers:
- Courtney Roberts, Ph.D.
- Department of Chemistry
- University of Michigan
- Ann Arbor