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  • Kevin Kou, Ph.D.
    12/05/17 - 9:45 AM to 11:00 AM

    Department Seminar: Kevin G.M. Kou, Ph.D.

    Department Seminar

"New Discoveries in Rhodium Catalysis and Total Syntheses of Diterpenoid Alkaloids"

Rhodium catalysis has been used to effect a number of synthetically important hydrofunctionalization transformations. In this seminar, an enantioselective, intermolecular, hydroacylation of ketones and dynamic kinetic resolution of allylic sulfoxides will be presented. Mechanistic investigations into these two reactions revealed unusual "dual role" natures of rhodium. The latter part of the seminar will focus on the syntheses of diterpenoid alkaloids, some of which have been shown to be modulators of voltage-gated ion channels. Here, the syntheses cochlearenine, N-ethyl-1a-hydroxy-17-veratroyldictyzine, and paniculamine will be presented.

  • Event Details

    Location: 331 Smith Hall
    Host: Professor Christopher Douglas
    Speakers:
    • Kevin G.M. Kou, Ph.D.
    • College of Chemistry
    • University of California, Berkeley

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