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  • Nicholas Race, Ph.R.
    12/07/17 - 9:45 AM to 11:00 AM

    Department Seminar: Nicholas J. Race, Ph.D.

    Department Seminar

"Application of mechanistic investigation and design in the development of new catalytic processes"

In this seminar, I will present two stories discussing the different ways mechanism can impact the development of new catalytic reactions. The first story describes the development of a copper‑catalyzed aza‑Heck cyclization of oxime esters for the synthesis of chiral nitrogen heterocycles. Mechanistic experiments were undertaken after reaction development was completed and provided insight into this new process such that a plausible mechanism could be described. The second story will outline how mechanistic rationale informed the design of a palladium‑catalyzed intermolecular, enantioselective coupling of oxygen nucleophiles and alkenes. Subsequent mechanistic study vindicated the earlier design principles and provided insight into an underdeveloped, fundamental mechanistic step.

  • Event Details

    Location: 331 Smith Hall
    Host: Professor Steven Kass
    • Nicholas J. Race, Ph.D.
    • Department of Chemistry
    • University of Utah
    • Salt Lake City

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