10/15/19 - 9:45 AM to 11:00 AM
Department Seminar: Professor Champak Chatterjee
Chemical Approaches to Investigate Eukaryotic Gene Transcription
Professor Chatterjee received his undergraduate degree in chemistry from the University of Bombay, and a master's degree in organic chemistry from the Indian Institute of Technology in Bombay. He performed doctoral studies at the University of Illinois at Urbana-Champaign, where he studied the mechanism of lantibiotic biosynthesis and developed a keen interest in the biology of post-translational protein modification. His post-doctoral work in synthetic protein chemistry at Rockefeller University focused on understanding the mechanism by which ubiquitin stimulates histone methylation, and developing new methods for the site-specific modification of proteins with ubiquitin and ubiquitin-like proteins.
Professor Chatterjee's lab is particularly interested in understanding how simple chemical modifications of proteins, that are found from bacteria to humans, have dramatic effects on protein structure and function. Researchers use a combination of organic synthesis and molecular biology to make semisynthetic proteins modified at specific amino acids. By studying the structure and function of these semisynthetic proteins under well-defined conditions that mimic living cells, they are learning how specific modified proteins work inside human cells.