10/17/19 - 9:45 AM to 11:00 AM
Department Seminar: Professor Douglas A. Michell
Professor Mitchell received his undergraduate degree in chemistry from Carnegie Mellon University. After a short internship in medicinal chemistry at Merck Research Laboratories, he obtained his doctorate from the University of California, Berkeley. For postdoctoral studies, he worked at the University of California, San Diego. He joined the University of Illinois faculty in 2009.
Professor Mitchell's primary research objective is to use a blend of chemical and biological approaches to address the alarming rise in antibiotic resistance. In this endeavour, researchers in his group seek to identify and characterize novel antibiotic compounds. Their research involves the characterization of novel natural products and employs synthetic methods to reveal both biological mode of action and structure-activity relationships. Further, researchers evaluate the mechanistic details of key biosynthetic enzymes for the purposes of analog generation. Taken together, their work aims to expedite the discovery of future medicines from biological sources. Of special interest are compounds that only kill pathogenic bacteria or directly target mechanisms of virulence. Unlike currently deployed antibiotics, which exclusively target essential life processes, their strategy holds great potential in delaying resistance.