10/13/16 -9:45 AM to 11:00 AM
Department Seminar: Professor Marcey Waters
"From Host-Guest Chemistry to the Nucleosome: Studies in Biomolecular Recognition"
Lysine and arginine methylation are two common post-translational modifications (PTMs) in histone proteins that trigger complex signaling events that control gene expression. Moreover, dysregulation of Lys and Arg methylation plays a role in many types of cancer. Thus, the “writers,” “readers,” and “erasors” of histone PTMs are all potential drug targets. To gain insight into this important class of protein-protein inter- actions, we have investigated the mechanism of binding and developed biomimetic molecular sensors as new tools to characterize these PTMs. Results of these studies will be presented.
Professor Waters' research group focuses on problems of molecular and biomolecular recognition. The research interests in her group span a wide range, from mechanistic organic chemistry and molecular recognition to structural biology, and hence involve the use of a variety of techniques. Methods used in the group include organic and solid phase synthesis, combinatorial chemistry, computational chemistry, molecular biology, kinetic and thermodynamic measurements using 1D and 2D NMR, circular dichroism, UV/Vis and fluorescence spectroscopy, analytical ultracentrifugation, and calorimetry.