02/06/20 - 9:45 AM to 11:00 AM
Dow Lecture Series: Professor Elizabeth R. Jarvo
Dow Lecture Series
Nickel-Catalyzed Stereospecific Cross-Coupling and Cross-Electrophile Coupling Reactions
Transition metal-catalyzed cross-coupling reactions have revolutionized the synthesis of natural products and medicinal agents and provided rapid synthetic access to a diverse range of molecules for biological testing. Important challenges remain, however, particularly in reactions that form C–C bonds between sp3 hybridized carbons. We are developing methods for stereospecific alkyl-alkyl cross coupling and cross-electrophile coupling reactions, where transposition of stereochemical information from the electrophilic starting material to the product occurs. Stereospecific reductive coupling reactions for synthesis of cis- and trans-substituted cyclopropanes will be described. Application of these methods in synthesis of known bioactive compounds and in discovery of compounds that exhibit selective anti-cancer activity will also be reported.
The focus of Professor Elizabeth Jarvo's research interests is the development of new reactions using organometallic catalysts, and application of these transformations in complex target-oriented synthesis. In addition to providing valuable synthetic methods, these studies test and deepen our understanding of the fundamental principles that underlie reactivity.
Jarvo is a professor of chemistry in the School of Physical Sciences at the University of California, Irvine. She earned her bachelor's degree from Acadia University and her doctorate from Boston College. She was post-doctoral fellow at Harvard University.