02/28/19 - 9:45 AM to 11:00 AM
Dow Lecture Series: Professor Joseph M. Fox
Dow Lecture Series
Fast, Multipurpose and Temporally Controlled Methods of Bioorthogonal Chemistry
Bioorthogonal reactions—chemical transformations that can proceed efficiently without interference from biological functionality—have had broad reaching implications for biomedicine and biotechnology. This seminar will describe the development and advancement of trans-cycloalkenes as tools for facilitating bioorthogonal labeling through reactions with s-tetrazines. Of the various click chemistries that have been pursued over the past decade, the tetrazine ligation enables the fastest reactivity. Described in this talk will be advances in computation and synthesis that have enabled the creation of coupling partners with rate constants that approach diffusion control.The seminar will describe recent applications of fast bioorthogonal chemistry to site selective protein modification, probing cellular oxidative stress and patterning biomaterials for tissue culture applications. The development of catalytic methods for ‘turning on’ the tetrazine ligation will be discussed, along with applications for intracellular catalysis, materials science and drug delivery.
Thursday, Feb. 28
Kate & Michael Bárány Conference Room (117/119 Smith Hall)
“Career Paths & Teaching”
Research in Professor Fox' group centers on the development of new types of chemical reactions, the application of these new reactions to the synthesis of naturally occurring and designed molecules with biological function, and in the use of design concepts in organic synthesis for applications in biology and materials science. His group has developed new syntheses and transformations of chiral cyclopropenes and trans-cycloalkenes, and a new type of bioorthogonal reaction that allows for extremely rapid conjugation to biological macromolecules. Applications of this work include synthesis of naturally occurring and designed molecules with biological function, and in the use of design concepts in organic synthesis for applications in biology, radiochemistry, imaging, therapy and materials science.
Joseph Fox is professor of chemistry in the Department of Chemistry and Biochemistry, where he also is the director of the National Institutes of Health-funded Center of Biomedical Research Excellence on Molecular Discovery. Fox received his bachelor’s degree from Princeton University, where he conducted undergraduate research as a Pfizer fellow with Maitland Jones Jr. He completed graduate studies under Professor Thomas Katz at Columbia University, where he developed a combined interest in materials science and the synthesis of challenging targets. He studied organometallic chemistry with Stephen Buchwald at MIT as an NIH postdoctoral fellow, where he worked on Pd-catalyzed ketone arylation and devised a synthesis of phosphine ligands that is now used commercially.