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  • Professor Mark Lautens
    11/08/18 - 9:45 AM to 10:45 AM

    Dow Lecture Series: Professor Mark Lautens

    Dow Lecture Series

Improving Efficiency vis Catalytic and Multicatalytic Reactions 

Oxidative addition and reductive elimination are two fundamental steps common to many different catalytic reactions. Insertion into C-X bonds is particularly prevalent as one of the first steps in a catalytic cycle. We have been exploring the synthetic potential associated with reversible oxidative addition into carbon-halogen bond and recently developed a metal catalyzed carboiodination reaction(1-2). This lecture will describe the scope and limitations of the reaction including recent work that has expanded the scope and led to the development of a metal catalyzed hydrohalogenation reaction(3). C-H functionalization remains one of the most active areas of research. We will present our recent work in this field highlighting C-H bond activation as a key step in spirocyclization reactions(4-5)

References
(1) Newman, S.G.; Lautens, M. Journal of the American Chemical Society 2011, 133, 1778-1780.
(2) Petrone, D.A.; Le, C.; Newman, S.G.; Lautens, M. New Trends in Cross Coupling: Theory and Applications, RSC, Colacot, T. Ed. 2014.
(3) Petrone, D.A.; Franzoni, I.; Ye, J.; Rodriguez, J.; Poblador-Bahamonde, A.; Lautens, M. Journal of the American Chemical Society2017, 139, 3546
(4) Ye, J. ; Shi, Z.; Sperger, T.; Yasukawa, Y.; Kingston, C.; Schoenebeck, F.; Lautens, M. Nature Chemistry, 2017, 9, 361-368.
(5) (4) Yoon, H.; Rolz, M; Lossouarn, A.; Landau, F.; Lautens, M. Angewandte Chemie International Edition, 2017, 56, 10920-10923

Open Forum

“Science Advocacy Why and How?”
4 p.m. to 5 p.m. Thursday, Nov. 8
Kate and Michael Bárány Conference Room (117/119 Smith Hall)

Professor Lautens

Professor Lautens' group is focused on the investigation and development of novel transition-metal-mediated organic transformations. Some projects include catalyst-controlled asymmetric transformations while others focus on controlled tandem or domino processes. Of particular interest are reactions that can efficiently construct frameworks of pharmaceutical compounds or fragments of biologically-active natural products. 

  • Event Details

    Location: 331 Smith Hall
    Host: Professor Nicholas Race
    Speakers:
    • Professor Mark Lautens
    • Mark Lautens
    • Department of Chemistry
    • University of Toronto