04/09/18 - 4:00 PM to 5:00 PM
Gassman Lectureship #1: Professor Samuel H. Gellman
Paul G. Gassman Lectureship in Chemistry
"Peptidic Foldamers: Extrapolating from Proteins"
Folded biopolymers perform diverse functions in biological systems. Most of these operations require the biopolymer chain to adopt a specific conformation. Over the past two decades there has been growing interest in the prospect that biopolymer functions might be recapitulated and perhaps even improved upon with unnatural oligomers that manifest discrete folding preferences. Such systems are referred to generically as “foldamers.” This lecture will provide an overview of the goals of this field, and progress toward those goals, with emphasis on contributions from my co-workers. We focus on peptidic oligomers that contain β-amino acid residues, exclusively or in combination with α-amino acid residues.
A reception follows this lecture
Kate & Michael Bárány Conference Room (117/119 Smith Hall)
Professor Samuel Gellman is the Ralph F. Herschmann Professor in the Department of Chemistry at the University of Wisconsin-Madison. He earned his A.B. degree from Harvard University, and his doctorate from Columbia University. He also was a post-doctorate fellow at the California Institute of Technology. His honors and awards include the Ronald Breslow Award for Achievement in Biomimetic Chemistry from the American Chemical Society, the Makineni Lecture Award from the American Peptide Society, and being named a Fellow of the National Academy of Sciences, and the American Academy of Arts and Sciences.
Research in Professor Gellman's laboratory encompasses the design, synthesis and evaluation of new types of molecules intended to display interesting structures and useful functions. In addition, researchers in his group seek to understand how proteins, the most diverse class of biomolecules, perform their natural functions. Research efforts require a range of experimental tools, including asymmetric organic synthesis, polymer synthesis, solid-phase peptide synthesis, high-resolution NMR and crystallographic analysis of molecular structure, protein expression biochemical assays, and cell-based assays. The research program is highly collaborative.
In honor of Regents Professor Paul G. Gassman
Regents Professor Paul G. Gassman died in April 1993, at the age of 57. He was internationally known in the chemical community, and left behind a legacy of achievement. During his career, he served as mentor and adviser to 85 doctoral and master’s candidates as well as dozens of postdoctoral associates and undergraduate students. Numerous awards, honors, and honorary degrees were bestowed in recognition of his contributions to research and his service to the scientific, professional, and university communities. Some of these awards include election to the National Academy of Sciences (1989) and to the American Academy of Arts and Sciences (1992); the James Flack Norris Award in Physical Organic Chemistry (1985); Arthur C. Cope Scholar Award (1986); and the National Catalyst Award of the Chemical Manufacturers Association (1990). He served as president of the American Chemical Society in 1990. He was co-chair of the organizing committees of the National Organic Symposium (1991) and the National Conferences on Undergraduate Research meeting (1992), on the University of Minnesota campus. It was his wish that a lectureship be established to bring distinguished organic chemists to the Department of Chemistry.