02/11/20 - 9:45 AM to 11:00 AM
Kolthoff Lectureship #2: Professor Catherine L. Drennan
Izaak M. Kolthoff Lectureship in Chemistry
Snapshots of Metalloenzymes Involved in Natural Product Biosynthesis
The natural product oxetanocin-A is a potent antiviral compound produced by Bacillus megaterium NK84-0128. The biosynthesis of oxetanocin-A has been linked to a plasmid-borne gene cluster that contains four genes involved in oxetanocin-A production (oxsA and oxsB) and oxetanocin-A resistance (oxrA and oxrB). In terms of the biosynthetic enzymes, OxsB is a cobalamin (Cbl)-dependent S adenosylmethionine (SAM) radical enzyme, and OxsA is an HD-domain phosphohydrolase enzyme. We have determined crystal structures of both OxsA and OxsB, and in this talk, I will present our current thinking about how these enzymes work together to transform dATP into oxetanocin-A, a process that involves a chemically challenging carbon skeletal rearrangement.
Kate and Michael Bárány Conference Room (117/119 Smith Hall)
Is the Classroom Lecture Becoming Extinct or Simply Evolving?
Catherine Drennan is a professor of chemistry and biology at the Massachusetts Institute of Technology, and a professor and investigator with the Howard Hughes Medical Institute. She received an AB (artium baccalaureus) in chemistry from Vassar College, and a doctorate in biological chemistry from the University of Michigan. She was also a post-doctoral fellow at the California Institute of Technology.
In 1999, she joined the faculty at the Massachusetts Institute of Technology. Professor Drennen's educational initiatives include creating free resources for educators that help students recognize the underlying chemical principles in biology and medicine, and that train graduate student teaching assistants and mentors to be effective teacher–scholars.
Professor Drennan’s primary research interest is the use of X–ray crystallography to study the structure and mechanism of metalloproteins. The primary targets of research in the Drennan lab are enzymes that contain metals or metallocofactors. These metalloenzymes use the enhanced reactivity of transition metals to catalyze challenging chemical reactions including radical-based chemistry and manipulation of organometallic bonds. The lab is also interested in metalloproteins that sense changes in the cellular environment and act as gene regulators. The Drennan lab also combines X-ray crystallography and electron microscopy with other techniques from biochemistry and biophysics to understand enzyme mechanisms—an approach called “structural metalloenzymology.”
Her awards include the Howard Hughes Medical Institute Investigator, Howard Hughes Medical Institute Professor, Everett Moore Baker Memorial Award for Excellence in Undergraduate Teaching, Harold E. Edgerton Faculty Achievement Award, Dean’s Educational and Student Advising Award, Alfred P Sloan Fellow, American Society of Biochemistry and Molecular Biology (ASBMB)–Schering–Plough Research Institute Scientific Achievement Award, Presidential Early Career Award for Scientists and Engineers, Searle Scholar, Cecil and Ida Green Career Development Chair, and Surdna Foundation Research Award.
Kolthoff Lectureship in Chemistry
Izaak Maurits Kolthoff was born on February 11, 1894, in Almelo, Holland. He died on March 4, 1993, in St. Paul, Minnesota. In 1911, he entered the University of Utrecht, Holland. He published his first paper on acid titrations in 1915. On the basis of his world-renowned reputation, he was invited to join the faculty of the University of Minnesota’s Department of Chemistry in 1927. By the time of his retirement from the University in 1962, he had published approximately 800 papers. He continued to publish approximately 150 more papers until his health failed. His research, covering approximately a dozen areas of chemistry, was recognized by many medals and memberships in learned societies throughout the world, including the National Academy of Sciences and the Nichols Medal of the American Chemical Society. Best known to the general public is his work on synthetic rubber. During World War II, the government established a comprehensive research program at major industrial companies and several universities, including Minnesota. Kolthoff quickly assembled a large research group and made major contributions to the program. Many of Kolthoff’s graduate students went on to successful careers in industry and academic life and, in turn, trained many more. In 1982, it was estimated that approximately 1,100 Ph.D. holders could trace their scientific roots to Kolthoff. When the American Chemical Society inaugurated an award for excellence in 1983, he was the first recipient.
Event DetailsLocation: 331 Smith HallHost: Professor Ambika Bhagi-Damodaran