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  • Professor Larry E. Overman
    10/31/19 - 9:45 AM to 11:00 AM

    Sigma-Aldrich Lecture: Professor Larry E. Overman

    Sigma-Aldrich Lecture

Synthesis of Structurally Elaborate Molecules by Fragment Coupling with Carbon Radicals

Reactions that allow complex molecular fragments to be combined in high yield occupy an exalted position in organic synthesis because they are fundamental to convergent synthesis strategies. Recent discoveries from our laboratories show that bimolecular reactions of structurally elaborate tertiary carbon radicals and electron-deficient alkenes can unite complex fragments by forming a new sp3–sp3 in good yield using near equimolar amounts of the two coupling partners. Reflecting the large steric bulk of tertiary carbon radicals, these reactions can take place with high stereoselectivity to form new quaternary and secondary carbon stereocenters. Tertiary carbon radicals are generated conveniently using visible-light photocatalysis, which offers distinct advantages over older less-green methods for forming carbon radicals.

Graphic for Professor Overman's seminar on Synthesis of Structurally Elaborate Molecules by Fragment Coupling with Carbon Radicals

Professor Overman

Professor Overman's research interests center on the invention of new reactions and strategies in organic synthesis and the total synthesis of natural products and their congeners. Total synthesis targets of our laboratory include agents displaying a variety of pharmacological activities. Researchers are also involved in collaborative programs in the areas of cancer biology, learning and memory, and tropical parasitic diseases.

Professor Overman received his bachelor's degree from Earlham College and his doctorate from the University of Wisconsin. He was a National Institutes of Health Post-doctoral Fellow at Columbia University before joining the faculty at the University of California, Irvine.

  • Event Details

    Location: 331 Smith Hall
    Host: Professor Christopher Douglas
    • Professor Larry E. Overland
    • Larry Overland
    • Department of Chemistry
    • University of California, Irvine