10/26/17 -9:45 AM to 11:00 AM
Sigma-Aldrich Seminar: Professor Sarah E. Reisman
"Necessity is the Mother of Invention: Natural Products and the Chemistry They Inspire"
The chemical synthesis of natural products provides an exciting platform from which to conduct fundamental research in chemistry and biology. Our group is currently pursuing the synthesis of a number of structurally complex natural products, including the diterpenoids ryanodine and talatisamine, and the antibiotic pleuromutilin. The densely-packed arrays of heteroatoms and stereogenic centers that constitute these polycyclic targets challenge the limits of current technology and inspire the development of new synthetic strategies and tactics. This seminar will describe the latest progress in our methodological and target-directed synthesis endeavors.
All are invited to an open forum with Professor Reisman at 4:30 p.m. Thursday, Oct. 26, in the Kate & Michael Barany Conference Room, 117/119 Smith Hall. Her topic, "Obtaining Work Life Balance."
Professor Reisman was born and raised in Bar Harbor, Maine. She attended Connecticut College in New London, CT, where she worked in the laboratory of Professor Timo Ovaska, and graduated with honors in 2001. In the fall of that year, sheenrolled in graduate studies at Yale University and joined the research group of Professor John Wood. She earned her doctorate in chemistry in 2006; her thesis detailed the total synthesis of the natural product welwitindolinone A isonitrile. For her post-doctoral work, Reisman pursued studies in the field of asymmetric catalysis as an National Institutes of Health fellow, working with Professor Eric Jacobsen at Harvard University. She joined the faculty at the California Institute of Technology in 2008. CV
The overarching goal of Professor Reisman's research program is to discover, develop, and study new chemical reactions within the context of natural product total synthesis. Her total synthesis efforts focus on structurally complex, stereochemically-rich targets that require innovative synthetic solutions, and that provide opportunities to engage in biological collaborations. Her reaction development efforts seek to address gaps in the existing technology as revealed by a complex target. These efforts have resulted in new methods for the preparation of pyrroloindolines and unnatural tryptophan derivatives, the development of arene cyclopropanation reactions and, most recently, the discovery of new Ni-catalyzed asymmetric reductive cross-coupling reactions. Within Reisman's methods development program, the discovery of new nickel-catalyzed asymmetric reductive cross-coupling reactions is of particular interest.
Event DetailsLocation: 331 Smith HallHost: Professor Christopher Douglas