09/27/17 -4:00 PM to 5:00 PM
Special Seminar: Professor David Michaelis
"Synthetic Applications of Enzyme-Inspired Catalysts"
Our research program is focused on using nature as an inspiration for the development of novel catalytic tools for organic synthesis. In the active site of enzymes, multiple metal centers often cooperate to lower the barrier to oxidative and reductive processes, thus enabling efficient catalysis in very challenging organic transformations. Our group is designing and developing heterobimetallic catalysts where metal-metal interactions and cooperativity can lead to enhanced catalysis and novel transformations. Our efforts have led to the development of Pd–Ti and Pt–Ti catalysts that display exceptional reactivity in allylic amination and cycloisomerization reactions respectively. This seminar will describe our current efforts to develop chiral Ti–M complexes for enantioselective catalysis and heterobimetallic M–Ni complexes for nickel catalysis applications. In separate pursuits, we have also developed peptide-based multifunctional catalysts that enable enzyme-like cooperative catalysis. The small peptide scaffold brings multiple non-natural catalysts into close proximity, enabling faster catalyst turnover, novel selectivity based on substrate binding and proximity, and the development of novel two-catalyst transformations. The development and use of these catalysts to achieve novel reaction rates and selectivity and for new reaction discovery will also be presented.
David Michaelis was raised in Salt Lake City and was an undergraduate student at Brigham Young University (BYU) in Provo, UT. As an undergraduate, he performed research with Professor Paul Savage on the development of organic sensors for cadmium ions. He received a Bachelor's degree in chemistry in 2005. Michaelis then attended graduate school at the University of Wisconsin–Madison where he worked with Tehshik P. Yoon. His graduate research focused on the development of novel oxidation reactions with oxaziridines, including for the copper-catalyzed oxyamination reaction of olefins. While at Wisconsin, he also participated in and was supported by the Chemistry Biology Interface Training Program (National Institutes of Health sponsored) and was the recipient of the American Chemical Society Division of Organic Chemistry graduate fellowship in 2008–2009. Michaelis' post-doctoral studies were with Barry M. Trost at Stanford University, where he was supported by a National Institutes of Health National Research Service Award post-doctoral fellowship. At Stanford, he worked on the development of several metal-catalyzed asymmetric methodologies, and on the synthesis of cytotoxic agent peloruside A. He started his independent career at BYU in April 2013. His research program focuses on the development of new enzyme-inspired catalysts for organic synthesis.