10/09/17 - 4:00 PM to 5:00 PM
Special Seminar: Professor Jennifer L. Stockdill
"Strategies and Methods for the Synthesis of Topologically Complex Natural Products"
Recent progress in the development of innovative new strategies and methods for the efficient synthesis of topologically complex bioactive natural products will be discussed. These methods are intended to be simple and reliable, facilitating ready adoption by researchers in related fields and use in contexts beyond the initial target. We are motivated by targets with long-standing synthetic challenges and promising bioactivity, such as polycyclic alkaloids bearing a tertiary aliphatic amine and disulfide- and thioether-linked and macrocyclic polypeptide natural products. These complimentary structural classes have great potential as lead targets and as biological tools. Chemical synthesis offers unparalleled flexibility in accessing analogs to tune the structure and improve selectivity for the target of interest, and new strategies and reaction methods expedite this process.
Research in Professor Stockdill's group is focused on the design of elegant and efficient strategies for the synthesis of complex natural products and for the synthesis and manipulation of proteins and related structures. Through these efforts, we explore chemical reactivity and develop new reaction methods. An overarching theme in the lab is to capitalize on the insights gained in each of the major synthetic areas to inspire and enable novel chemistry in the other.
Professor Jennifer "Jenn" L. Stockdill completed her undergraduate studies at Virginia Tech in Blacksburg, VA, where she graduated magna cum laude with a Bachelor of Science degree in chemistry in 2003. From there, she moved to Pasadena, CA, where she completed a doctorate in chemistry in 2009 under the guidance of Professor Brian M. Stoltz at Caltech. Her thesis work focused on the synthesis of the bioactive marine alkaloid zoanthenol. Through this synthetic effort, she completed the cyclization of aromatic systems by both acid-mediated and radical-mediated methods to form the densely functionalized carbocyclic core of zoanthenol. She then joined the group of Professor Samuel J. Danishefsky at the Sloan-Kettering Institute at MSKCC. Her research efforts during this time spanned several areas including the study of isonitrile-based methods for amide bond formation, the application of these reactions to the synthesis of cyclosporine, the conversion of N-formyl amides to optically active hydantoins, and the total chemical synthesis of the pituitary glycoprotein human thyroid-stimulating hormone (hTSH). She joined the faculty of the Department of Chemistry at Wayne State University as an assistant professor in July 2012.