10/09/17 -4:00 PM to 5:00 PM
Special Seminar: Professor Jennifer L. Stockdill
"Strategies and Methods for the Synthesis of Topologically Complex Natural Products"
Research in the Stockdill group is focused on the design efficient strategies for the synthesis of bioactive molecules ranging from polycyclic alkaloids to disulfide-linked mini-proteins and macrocyclic polypeptides. In the course of these efforts, we explore chemical reactivity and develop new reaction methods. This seminar will highlight our recent progress in these areas.
Professor Jennifer "Jenn" L. Stockdill completed her undergraduate studies at Virginia Tech in Blacksburg, VA, where she graduated magna cum laude with a Bachelor of Science degree in chemistry in 2003. From there, she moved to Pasadena, CA, where she completed a doctorate in chemistry in 2009 under the guidance of Professor Brian M. Stoltz at Caltech. Her thesis work focused on the synthesis of the bioactive marine alkaloid zoanthenol. Through this synthetic effort, she completed the cyclization of aromatic systems by both acid-mediated and radical-mediated methods to form the densely functionalized carbocyclic core of zoanthenol. She then joined the group of Professor Samuel J. Danishefsky at the Sloan-Kettering Institute at MSKCC. Her research efforts during this time spanned several areas including the study of isonitrile-based methods for amide bond formation, the application of these reactions to the synthesis of cyclosporine, the conversion of N-formyl amides to optically active hydantoins, and the total chemical synthesis of the pituitary glycoprotein human thyroid-stimulating hormone (hTSH). She joined the faculty of the Department of Chemistry at Wayne State University as an assistant professor in July 2012.
Research in Professor Stockdill's group is focused on the design of elegant and efficient strategies for the synthesis of complex natural products and for the synthesis and manipulation of proteins and related structures. Through these efforts, we explore chemical reactivity and develop new reaction methods. An overarching theme in the lab is to capitalize on the insights gained in each of the major synthetic areas to inspire and enable novel chemistry in the other.