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  • Professor Samir Z. Zard
    06/05/19 - 9:45 AM to 11:00 AM

    Special Seminar: Professor Samir Z. Zard

    Special Seminar

Reversible Reservoirs for Radicals. New Perspectives for Organic Synthesis and for Polymer Chemistry

Radical reactions offer many of the properties desired by synthetic organic chemists, in terms of variety, mildness of conditions, and a selectivity that is often complementary to that of ionic chemistry, making many protection steps superfluous. There is however one major difficulty, which derives from the propensity of radicals to interact with themselves (dimerisation, disproportionation) with extremely fast rates that are close to diffusion. In order to overcome this complication, it is essential to keep the steady-state concentration of radical species very low. This can be accomplished for example by contriving a chain reaction where the propagating steps are themselves quite fast, as for example in the typical, and now extremely popular, stannane based processes. While various unimolecular cyclisation and fragmentation steps can be efficiently incorporated into the radical sequence, kinetically slower bimolecular transformations, and in particular intermolecular additions to un-activated alkenes, have proven more difficult to implement. In the case of stannanes, the relatively slow addition to the alkene has to compete with premature hydrogen atom abstraction from the organotin hydride, a step that is usually thousands of times faster.

Over the years, we have shown that xanthates and related thiocarbonylthio derivatives allow the generation of radicals under conditions where the radicals possess a considerably increased effective lifetime, even in a concentrated medium. Intermolecular additions to un-activated alkenes as well as a variety of reputedly difficult radical transformations can now be easily accomplished. No metals, heavy or otherwise, are required, and the starting materials and reagents are cheap and readily available. Complex, densely functionalized structures can be constructed in a convergent, modular fashion. This chemistry has also proved to be applicable to the synthesis of block polymers and for exploiting bio-sourced raw material. Recent results and some mechanistic aspects will be presented and discussed briefly.

Professor Zard

Samir Z. Zard was born in Nigeria. His training as a chemist started at the American University of Beirut, then at Imperial College, London, and finally at the Université Paris-Sud, France. He now has the rank of Director of Research - Exceptional Class in the CNRS - and professor of organic chemistry at Ecole Polytechnique. His main research interests concern the study and development of new reactions and processes, with a particular emphasis on the chemistry of organosulfur and organofluorine derivatives, alkynes, nitro compounds, and radicals. Work in the last area has resulted in the powerful RAFT-MADIX process for controlled polymerization, which allows the industrial production of block polymers. He has authored or co-authored 260 papers and 32 patents, and presented nearly 400 invited lectures and seminars at national and international meetings and universities.

He was a Fellow of the Chemistry Research Promotion Center of the National Science Council of Taiwan, Astra-Zeneca USA Lecturer, Sherbrooke-Bohringer Ingelheim Canada Lecturer, Bürgenstock Lecturer, Merck Sharpe & Dohme Lecturer, Fellow of the Japan Society for the Promotion of Science, Novartis-UC Irvine Lecturer, Novartis-Berkeley Lecturer, and Bristol-Myers Squibb-Scripps Institute Lecturer .

His scientific awards and honors include the 1992 Prize of the Organic Chemistry Division of the French Chemical Society, the 1995 Clavel-Lespiau Prize of the French Academy of Science, the Rhodia Prize in 2000, the Dargelos Prize in 2006, the Novartis Chemistry Lectureship for 2006-2007, the Silver Medal of the CNRS in 2007, the Presidency of the Bürgenstock Conference in 2007. In 2003, he was promoted Chevalier des Palmes Académiques and, in 2007, received the Croix de Chevalier de la Légion d’Honneur.

  • Event Details

    Location: 331 Smith Hall
    Host: Professor Thomas Hoye
    Speakers:
    • Professor Samir Z. Zard
    • Samir Zard
    • Laboratoire de Synthèse Organique
    • Ecole Polytechniquen
    • Paris