11/09/16 - 11:45 AM to 12:45 PM
Special Seminar: Professor Yun Chen
"Quantitative Analysis of Biomolecules using LC-MS/MS-based Targeted Proteomics"
The sensitivity and specificity of current breast cancer biomarkers are not sufficient for early diagnosis. Identification of more sensitive and specific biomarkers to provide accurate information about disease at the molecular level is of great significance to establish new breast cancer diagnosis model. To achieve this goal, one of prerequisites is to accurately profile the expression of biomarker candidates. However, most of the currently available assays frequently fail to provide adequate reproducibility and specificity for the quantification of biomolecules. Liquid chromatography-tandem mass spectrometry (LC-MS/MS)-based targeted proteomics emerges as alternative technique. Recent work in our lab has shown a clear advantage of targeted proteomics in quantitative analysis of proteins, modified proteins, protein complexes and other biomolecules.
Professor Chen's research interests include the evelopment and validation of liquid chromatography-tandem mass spectrometry (LC-MS/MS)-based targeted proteomics assays for biomarker analysis and discovery; sample enrichment and pretreatment for low-abundant biomarkers; and investigation of drug-resistance mechanism.
Event DetailsLocation: Kate & Michael Bárány Conference Room (117/119 Smith Hall)Host: Professor Edgar ArriagaSpeakers:
- Professor Yun Chen
- School of Pharmacy
- Nanjing Medical University