09/26/19 - 9:45 AM to 11:00 AM
Student Seminar Series: Professor Andrew McNally
Student Seminar Series
Selective Functionalization of Pyridines, Diazines and Pharmaceuticals using Phosphorus Ligand-Coupling Reactions
Selective methods that can functionalize electron-deficient heterocycles are in great demand due to their prevalence in biologically active compounds. Pyridines and diazines, in particular, are widespread components of pharmaceutical compounds yet methods to transform these motifs into valuable derivatives are still greatly sought after. We will present a selection of catalytic and non-catalytic methods using phosphorus intermediates that enable multiple new bond-constructions on these heterocycles. A particular emphasis will be placed on phosphorus ligand-coupling reactions that represent an alternative means to form C–C and C-Heteroatom bonds.
A broad aim in Professor McNally's lab is to develop new catalytic reactions to access molecules with desirable properties whether they be key chemical building blocks or substances vital for human health. The unique ability of synthetic chemists to control and direct the reactivity of molecules combined with the influence of new technology is integral toward this goal. This includes sustainable catalysis, developing new catalytic methods to transform these ubiquitous molecules into useful chemicals and provide access to low-cost fuels, fine chemicals, pharmaceuticals and polymeric materials; asymmetric catalysis, developing catalytic asymmetric process on non-typical precursors such as aromatic heterocyles and amines, which can enable rapid and direct construction of complex molecules synonymous with useful biological properties; and new reaction development and high-throughput techniques, using a combination of traditional and high-throughput techniques when developing new reactions and exploring problems outside of the remit of typical laboratory techniques.
Professor Andrew McNally grew up in Liverpool in the United Kingdom. He gained his undergraduate degree and his doctorate from the University of Cambridge. He was awarded a Marie Curie International Outgoing Fellowship and moved to Princeton University to work as a post-doctoral researcher. For the second phase of the fellowship, he returned to Cambridge and worked on the C–H activation reactions of aliphatic amines. He began his independent career in 2014 at Colorado State University.