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  • Larry Que

    Regents Professor, Distinguished University Teaching Professor

    • Inorganic & Organometallic Chemistry, Bioinorganic Chemistry
    • Chemical Biology, Nonheme Iron Enzymes
    • Environmental & Green Chemistry, Enzymatic Oxidation
    • Energy & Catalysis
    • B.S. Ateneo de Manila University, 1969
    • Ph.D. University of Minnesota, 1973 (Louis H. Pignolet)
    • Post Doctorate Massachusetts Institutes of Technology (Richard H. Holm), University of Minnesota (Eckard Münck), 1973-1977
    Office: 343 Smith Hall

Principal Research Interests

Our group focuses on bio-inorganic chemistry, specifically on the topic of iron, oxygen and (bio)catalysis. Our research effort, involving a combination of biochemical, synthetic inorganic, and spectroscopic approaches, is aimed at elucidating the oxygen activation mechanisms of nonheme iron enzymes, designing functional models for such enzymes, trapping and characterizing reaction intermediates, and developing bio-inspired oxidation catalysts for green chemistry applications. The pictures illustrate the crystal structure of a recently isolated oxoiron(IV) complex with the oxo atom syn to the methyl groups of the TMC macrocycle (left) and a DFT-calculated structure for a reactive intermediate that we have trapped in our efforts to develop bio-inspired iron catalysts for hydrocarbon oxidation (right).

crystal structure of a recently isolated oxoiron(IV) complex with the oxo atom syn to the methyl groups of the TMC macrocycle
 
Larry Que research graphic 2
 
 

Honors and Awards

  • American Chemical Society Award in Inorganic Chemistry, 2017
  • Japan Society of Coordination Chemistry International Award, 2015
  • John C. Bailar Jr. Medal from University of Illinois Urbana-Champaign, 2012
  • Elected American Chemical Society Fellow 2011
  • Royal Society of Chemistry Inorganic Reaction Mechanisms Award, 2011
  • Designated Fellow of the Royal Society of Chemistry, 2008
  • American Chemical Society Alfred Bader Award in Bioinorganic or Bioorganic Chemistry, 2008
  • Frontiers in Biological Chemistry Award from the Max-Planck-Institut für Bioanorganishe Chemie, 2005
  • Elected Fellow of the American Association for the Advancement of Science, 2001
  • National Institutes of Health MERIT Award 2000-2010
  • University of Minnesota Award for Outstanding Contributions in Post-Baccalaureate, Graduate, and Professional Education, 1999-2000
  • National Institutes of Health Research Career Development Award, 1982-87
  • Alfred P. Sloan Research Fellowship, 1982-86

Mailing Address

  • Lawrence Que, University of Minnesota, Department of Chemistry
  • B-16, 139 Smith Hall, 207 Pleasant St SE
  • Minneapolis, MN 55455-0431