Timothy J. Griffin
Associate Professor (College of Biological Sciences)
- Chemical Biology
Principal Research Interests
Work in our group involves the development and application of mass spectrometry-based tools to study proteins and proteomes. The goal of this work is to provide the necessary tools to enable the system-wide characterization of proteins expressed within a cell, tissue, biological fluid or organism, in order to better understand basic mechanisms of biological function and disease. These tools must be capable of measuring the many properties of proteins that collectively determine their function. These properties include protein abundance, sub-cellular localization, post-translational modifications, associations in non-covalent complexes and biochemical activity. Mass spectrometry provides a highly powerful tool that can aid in measuring these various protein properties, in a high-throughput manner. The development and application of these tools is highly interdisciplinary in nature, integrating front-end molecular biology and biochemical methods, protein and peptide chemistry, analytical separations, instrumental analysis, and back-end computation and bioinformatics for data analysis and biological interpretation.
- Timothy J. Griffin, University of Minnesota, Department of Chemistry
- Molecular & Cellular Biology (delivery code 1231), 139 Smith Hall, 207 Pleasant St SE
- Minneapolis, MN 55455-0431