Our faculty and students are on the front line of this exciting field, developing new techniques and integrating modern chemical methods to understand biological problems at the molecular level. Recent technological breakthroughs present spectacular new opportunities to address problems in pharmacology, cell biology, structural biology, and medicine. State-of-the-art facilities in structural biology make the University of Minnesota an excellent choice for the biological chemist who wishes to correlate detailed molecular structure with biological function.

Research Topics

  • synthesizing potent bioactive molecules including anti-cancer compounds and natural products 
  • developing chemical methods for synthesis of small molecules, peptides and small proteins, engineering designer proteins, 
  • mimicking metalloprotein active sites and examining reactivity of model complexes 
  • using a combination of biochemical, inorganic, and synthetic organic chemistry to study how these fascinating catalysts function at the molecular level
  • conducting single cell, organelle, and molecule analysis 
  • studying the redox properties of enzymes 
  • designing novel bioactive nanomaterials 
  • conducting in-situ neurochemistry 
  • performing theoretical and computational studies of the structure, reactivity, and dynamics of biomolecules in solution
  • modeling enzymatic catalysis
  • using fluorescence, IR, Raman, EPR, and NMR spectroscopies to study exciting problems and protein-RNA interactions, HIV, membrane-bound proteins, and metalloproteins
  • conducting in vitro selection (SELEX) to obtain new diagnostic and therapeutic agents
  • developing and using new methods for proteomic analysis
  • determining the structure of proteins via NMR methods
  • studying the mechanisms of DNA damage and repair
  • creating new protein-based therapeutics
  • developing new methods for super resolution microscopy

Faculty

  • Edgar Arriaga
    • Analytical & Bioanalytical Chemistry
    • Chemical Biology
  • George Barany
    • Chemical Biology
    • Organic Chemistry
  • Michael Bowser
    • Analytical & Bioanalytical Chemistry
    • Chemical Biology
  • Erin Carlson
    • Chemical Biology
    • Organic Chemistry
    • Analytical & Bioanalytical Chemistry
    • Nanoscience & Materials Chemistry
    • Environmental & Green Chemistry
  • Mark Distefano
    • Chemical Biology
    • Organic Chemistry
  • Renee Frontiera
    • Analytical & Bioanalytical Chemistry
    • Nanoscience & Materials Chemistry
    • Chemical Biology
    • Experimental Physical Chemistry
    • Chemical Physics
    • Energy & Catalysis
  • Jiali Gao
    • Chemical Biology
    • Chemical Physics
    • Chemical Theory & Computation
    • Organic Chemistry
    • Energy & Catalysis
  • Gunda Georg
    • Organic Chemistry
    • Chemical Biology
  • Timothy Griffin
    • Organic Chemistry
    • Chemical Biology
  • Daniel Harki
    • Organic Chemistry
    • Chemical Biology
  • Carrie Haskell-Luevano
    • Chemical Biology
  • Christy Haynes
    • Nanoscience & Materials Chemistry
    • Analytical & Bioanalytical Chemistry
    • Chemical Biology
    • Inorganic & Organometallic Chemistry
    • Environmental & Green Chemistry
    • Chemical Physics
  • Thomas Hoye
    • Organic Chemistry
    • Polymer Chemistry
    • Chemical Biology
    • Environmental & Green Chemistry
    • Inorganic & Organometallic Chemistry
    • Nanoscience & Materials Chemistry
  • John Lipscomb
    • Chemical Biology
    • Inorganic Chemistry
    • Physical Chemistry
  • Valerie C. Pierre
    • Inorganic & Organometallic Chemistry
    • Analytical & Bioanalytical Chemistry
    • Chemical Biology
    • Organic Chemistry
  • William Pomerantz
    • Chemical Biology
    • Organic Chemistry
    • Analytical & Bioanalytical Chemistry
  • Lawrence Que
    • Inorganic & Organometallic Chemistry
    • Chemical Biology
    • Environmental & Green Chemistry
    • Energy & Catalysis
  • Theresa Reineke
    • Nanoscience & Materials Chemistry
    • Chemical Biology
    • Polymer Chemistry
  • William Tolman
    • Inorganic & Organometallic Chemistry
    • Organic Chemistry
    • Chemical Biology
    • Polymer Chemistry
    • Energy & Catalysis
  • Joseph Topczewski
    • Organic Chemistry
    • Inorganic & Organometallic Chemistry
    • Environmental & Green Chemistry
    • Polymer Chemistry
    • Chemical Biology
  • Natalia Tretyakova
    • Chemical Biology
  • Donald Truhlar
    • Chemical Physics
    • Chemical Theory & Computation
    • Environmental & Green Chemistry
    • Nanoscience & Materials Chemistry
    • Energy & Catalysis
    • Chemical Biology
  • Gianluigi Veglia
    • Chemical Biology
    • Chemical Physics
    • Experimental Physical Chemistry
  • Carston R. Wagner
    • Chemical Biology