Agilent 7200 GC/QTOF-MS

Agilent GC_QTOF

The Agilent 7200 GC/QTOF-MS is a directly combined gas chromatograph-quadrupole time-of-flight mass spectrometer for accurate mass GC/MS and GC/MS/MS measurements. This instrument, acquired in 2015 with a University of Minnesota Research Infrastructure Investment Program Award, significantly expands the University’s capabilities in characterizing a wide range of chemical species, from small molecules and metabolites to synthetic polymers.

  • fosters interdisciplinary and intercollegiate research collaborations,
  • advances understanding of the chemical mechanisms of disease,
  • accelerates development of next-generation polymeric materials, and
  • leads the way on the design, synthesis and characterization of new compounds and materials.
 

BioToFESI

Bruker BioTOF II ESI/TOF-MS

The Bruker BioTOF II ESI/TOF-MS is a reflectron ESI-TOF instrument capable of 20,000 resolving power (FWHM) in its multipass mode of operation. It is used primarily for open-access ESI accurate mass measurements.

  • Infusion only
  • Mass Range: 2000 m/z

Waters TQD UPLC/Triple Quadrupole-MS

Waters TQD

The Waters TQD UPLC/Triple Quadrupole-MS combines ultra performance liquid chromatography with photodiode array (UV) and triple quadrupole mass spectrometric (MS/MS) detection for highly selective and sensitive characterization of compounds in complex mixtures.


Waters Synapt G2QTOF

Waters Synapt G2 UPLC/QTOF-MS

The Waters Synapt G2 UPLC/QTOF-MS combines ultra performance liquid chromatography with accurate mass MS, MS/MS and MS(e) with the ability to perform simultaneous ion mobility separation. This allows for highly selective and sensitive characterization of compounds in complex mixtures.


MALDI 4800

Applied Biosystems-Sciex 4800 MALDI/TOF/TOF-MS

Applied Biosystems-Sciex 4800 MALDI/TOF/TOF-MS is a powerful tool for analyzing a variety of different analytes, including small molecules (metabolites), lipids, nucleic acids, peptides, proteins, and polymers ranging in molecular mass from 100 Da up to 100 kDa or more.

  • For analysis by MALDI, a sample is mixed or coated with an energy-absorbing matrix and then irradiated with a laser beam (typically a Nd:Yag laser).
  • Singly protonated (positive ionization mode) or deprotonated (negative ionization mode) molecular ions are formed and detected by a time-of-flight mass analyzer.
MALDI 5800

Applied Biosystems-Sciex 5800 MALDI/TOF/TOF-MS

Applied Biosystems-Sciex 5800 MALDI/TOF/TOF-MS is a powerful tool for analyzing a variety of different analytes including small molecules (metabolites), lipids, nucleic acids, peptides, proteins, and polymers ranging in molecular mass from 100 Da up to 100 kDa or more.

  • For analysis by MALDI, a sample is mixed or coated with an energy-absorbing matrix and then irradiated with a laser beam (typically a Nd:Yag laser).
  • Singly protonated (positive ionization mode) or deprotonated (negative ionization mode) molecular ions are formed and detected by a time-of-flight mass analyzer.

The 5800 TOF/TOF is also capable of MALDI Imaging Mass Spectrometry (MALDI IMS).

  • MALDI IMS is accomplished by acquiring mass spectra across material or tissue areas.
  • A two-dimensional optical image of each material slice reveals the spatial distribution of chemicals on that slice to 10-50 μm resolution.
  • A user can then select mass values for compounds of interest and “stain” the image with mass-specific colors.
  • Each pixel on the color-coded image contains a detailed mass spectral analysis of compounds localized at that spot.

Cytof

Fluidigm CyTOF2 Mass Cytometer

Mass Cytometry combines the advantages of single cell high speed analysis common to conventional flow cytometry with the ability to resolve more than 100 metal probes with minimal signal overlap common to atomic mass spectroscopy; thereby, providing researchers with an unparalleled ability to phenotypically and functionally profile cells from normal and diseased states.

  • The Fluidigm mass cytometry platform includes the MaxPar® line of metal-conjugated probes, the CyTOF Mass Cytometer, and high dimensional analysis tools from DVS Cytobank.
  • Information on this platform, its uses and support can be found at the University's Mass Cytometry Initiative webpage.

To schedule time on the instruments, go to the Mass Spec Instrument Scheduling Site and log in as a guest or by using your account name and password. 

Contact

  • Mailing address
    Mass Spectrometry Laboratory
    Department of Chemistry
    University of Minnesota
    207 Pleasant St SE
    Minneapolis, MN 55455

    • Mass Spectrometry Laboratory
    • 191 Kolthoff Hall, 225 Pleasant St SE, Minneapolis, MN 55455
    • Joseph J. Dalluge, Ph.D., Director
    • chmmslab@umn.edu
    • (612) 625-8099