In addition to its core services, the Mass Spectrometry Laboratory conducts collaborative research programs with investigators from the departments of Chemistry, Biological Sciences, and Medicine. Current efforts focus on the sensitive detection and quantification of medically relevant diagnostic markers, metabolite profiling for identification of biomarkers relevant to human health, and metabolite profiling approaches to biodiversity research. In June 2011, the laboratory was named a Waters Center of Innovation for Mass Spectrometry.

Recent Publications

  • Meyer, A.F., Gruba, S.M., Kim, D., Meyer, B.M., Koseoglu, S., Dalluge, J.J., Haynes, C.L. Stereochemistry- and Concentration-Dependent Effects of Phosphatidylserine Enrichment on Platelet Function. Biochim. et Biophys. Acta-Biomembranes (2017) DOI: 10.1016/j.bbamem.2017.04.027.
  • Satori, C.P., Ramezani, M., Koopmeiners, J.S., Meyer, A.F., Rodriguez-Navarro, J.A., Kuhns, M.M., Taylor, T.H., Haynes, C.L., Dalluge, J.J., Arriaga, E.A. Checkpoints for Preliminary Identification of Small Molecules Found Enriched in Autophagosomes and Activated Mast Cell Secretions Analyzed by Comparative UPLC/MSe. Anal. Methods (2016) DOI: 10.1039/C6AY02500E.
  • Dalluge, J.J1., McCurtain, J.L., Gilbertsen, A.J., Kalstabakken, K.A., Williams, B.J. Determination of Agmatine Using Isotope Dilution UPLC-Tandem Mass Spectrometry: Application to the Characterization of the Arginine Decarboxylase Pathway in Pseudomonas aeruginosa. Anal. Bioanal. Chem. DOI: 10.1007/S00216-015-8724-0.
  • K. Wende, P. Williams, J. Dalluge, W. van Gaens, H. Aboubakr, J. Bischop, Th. von Woedtke, S. M. Goyal, A. Bogaerts, K. Masur, P.J. Bruggeman. Identification of the biologically active liquid chemistry induced by a nonthermal atmospheric pressure plasma jet. Biointerfaces. DOI: 10.1116/1.4919710.
  • Paulsen, N.B., Gilbertsen, A.J., Dalluge, J.J., Welchilin, C.W., Hughes, J., Han, W., Blackwell, T.S., Laguna, T.A., Williams, B.J. The Arginine Decarboxylase Pathways of Host and Pathogen Interact to Impact Inflammatory Pathways in the Lung. PLOS ONE 9 (2014) doi:10.1371/journal.pone.0111441
  • Koseoglu, S., Meyer, A.F., Kim, D., Meyer, B.M., Wang, Y., Dalluge, J.J., Haynes, C.L. Analytical Characterization of the Role of Phospholipids in Platelet Adhesion and Secretion. Anal. Chem. 87 (2015) 413-421.
  • Wollack, J.W., Monson, B.J., Dozier, J.K., Dalluge, J.J., Poss, K., Hilderbrand, S.A., Distefano, M.D. Site-Specific Labeling of Proteins and Peptides with Trans-Cyclooctene Containing Handles Capable of Tetrazine Ligation. Chem. Biol. Drug Des. 84 (2014) 140-147.
  • Dalluge, J.J., Connell, L.B. On the Potential of Mass Spectrometry-Based Metabolite Profiling Approaches to the Study of Biochemical Adaptation in Psychrophilic Yeast. Extremophiles (2013) 953-961.
  • Connell, L.B., Rodriguez, R.R., Redman, R.S., Dalluge, J.J. Cold-Adapted Yeasts in Antarctic Deserts. In P. Buzzini, R. Margesin (eds.) Cold-Adapted Yeasts, DOI: 10.1007/978-3-642-39681-6_4, Springer-Verlag Berlin Heidelberg 2013.
  • Meyer, A.F., Thompson, J.W., Wang, Y., Koseoglu, S., Dalluge, J.J., Haynes, C.L. Isotope-Dilution UPLC-MS/MS Determination of Cell-Secreted Bioactive Lipids. Analyst 138 (2013) 5697-5705.
  • Gruba, S.M., Meyer, A.F., Manning, B.M., Wang, Y., Thompson, J.W., Dalluge, J.J., Haynes, C.L. Time- and Concentration-Dependant Effects of Exogenous Serotonin and Inflammatory Cytokines on Mast Cell Function. ACS Chem. Biol. (2013) 503-509.
  • Mbughuni, M.M., Chakrabarti, M., Hayde, J.A., Meier, K.K., Dalluge, J.J., Hendrich, M.P., Munck, E., Lipscomb, J.D. Oxy-Intermediates of Homoprotocatechuate 2,3-Dioxygenase: Facile Electron Transfer Between Substrates. Biochemistry 50 (2011) 10262-10274.
  • Ross, K.L. and Dalluge, J.J. Liquid Chromatography/Tandem Mass Spectrometry of Glycolytic Intermediates: Deconvolution of Coeluting Structural Isomers Based on Unique Product Ion Ratios. Anal. Chem. 81 (2009) 4021-4026.
  • Ross, K.L., Tu, T.T., Smith, S., Dalluge, J.J. Profiling of Organic Acids during Fermentation by Ultraperformance Liquid Chromatography-Tandem Mass Spectrometry. Anal. Chem. 79 (2007) 4840-4844.